Synthesis of Novel Room Temperature Chiral Ionic Liquids. Application as Reaction Media for the Heck Arylation of Aza-endocyclic Acrylates
نویسندگان
چکیده
Novos líquidos iônicos aquirais e quirais foram preparados utilizando-se rotas sintéticas inéditas e/ou otimizadas. Estas séries de líquidos iônicos do tipo imidazolínico, imidazólico e piridínico foram totalmente caracterizadas, incluindo-se análises por calorimetria diferencial de varredura (DSC). O desempenho desses líquidos iônicos (LIs) foi demonstrado empregando-se a arilação de Heck de aza-acrilato endocíclicos com sais de arenodiazônio ou iodetos de arila. As arilações de Heck realizadas na presença destas entidades iônicas quirais, seja como um solvente ou um aditivo, foram eficazes levando à completa conversão do substrato, em bons a excelentes rendimentos do aduto de Heck na maioria dos casos, apesar de não ser observada indução assimétrica em nenhum dos casos estudados. Dois novos complexos quirais de paládio do tipo carbeno N-heterocíclico foram preparados em bons rendimentos a partir de um sal imidazólico quiral e suas estruturas caracterizadas por difração de raios-X. De modo geral, a arilação de Heck empregando tetrafluoroboratos de arenodiazônio em líquidos iônicos demonstrou ser mais eficiente do que os protocolos tradicionais em termos de reatividade e rendimentos de reação.
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